Exodus 7:16: And thou shalt say unto him, The LORD God of the Hebrews hath sent me unto thee, saying, Let my people go, that they may serve me in the wilderness: and, behold, hitherto thou wouldest not hear.
It was sacrilege for Egypt to lay hands on God's anointed. To lay godless hands on any man by word thought or deed is a sin. To impede the word, service, and ministry of God is a sacrilege. The sacrilege of persons thus is the violation or abuse of the priests and ministers of God who serve their Lord faithfully and obey His laws. It is also the violation of the covenant man, whatever his calling, when he is persecuted for the Lord's sake, it is done to Him also (Matt 25:40,45).